Selected publications 2016 – 2021

Immunotherapy offers new molecular strategies to treat bacterial infections. Invited review.

Butler DSC, Wan M, Ambite I, Hien Tran T, Wullt B and Svanborg C.

Nature Reviews Urology

A novel, peptide-based approach for targeting and killing tumor cells with greater precision.

Brisuda A, Ho JCS, Kandiyal PS, Ng JTY, Ambite I, Butler DSC, Háček J, Wan MLY, Hien Tran T, Nadeem A, Hiep Tran T, Hastings A, Storm P, Fortunati DL, Esmaeili P, Novotna H, Horňák J, Mu YG, Mok KH, Babjuk M and Svanborg C.

Nature Communications, in press.

Molecular determinants of disease severity in urinary tract infection.

Ambite I, Butler DSC, Wan MLY, Rosenblad T, Tran TH Chao SM and Svanborg C.

Nature Reviews Urology, in press

A bacterial protease depletes c-MYC and increases survival in mouse models of bladder and colon cancer.

Butler DSC, Cafaro C, Putze J, Wan MLY, Tran TH, Ambite I, Ahmadi S, Kjellström S, Welinder C, Chao SM, Dobrindt U and Svanborg C.

Nature Biotechnology, 2021

Active bacterial modification of the host environment through RNA Polymerase II inhibition

Ambite I, Filenko N, Zaldastanishvili E, Butler DSC, Tran TH, Chaudhuri A, Esmaeili P, Ahmadi S, Paul S, Wullt B, Putze J, Chen SL, Dobrindt U and Svanborg C.

Journal of Clinical Investigation, 2021

Peptide-oleate complexes create novel membrane-bound compartments

Hansen JS, Tran TH, Cavalera M, Paul S, Chaudhuri A, Lindkvist-Petersson K, Ho J and Svanborg C.

Molecular biology and evolution, 2020

Bladder cancer treatment without toxicity – A dose-escalation study of Alpha1-Oleate

Tran T Hien, Ambite I, Butler D, Höglund U, Babjuk M, Wan MLW, Tran T Hiep and Svanborg C.

International Journal of Cancer, 2020

Fimbriae reprogram host gene expression – divergent control by P and type 1 fimbriae

Ambite I, Butler DSC, Stork C, Grönberg-Hernández J, Köves, B, Zdziarski, J, Pinkner J, Hultgren SJ, Dobrindt, U, Wullt, B and Svanborg, C.

PloS Pathogens, 2019

Beta-sheet-specific interactions with heat shock proteins define a mechanism of delayed tumor cell death in response to HAMLET.

Nadeem A, Ho J, Tran TH, Paul S, Granqvist V, Despretz N and Svanborg C.

Journal of Molecular Biology, 2019

Neuroepithelial control of mucosal inflammation in acute cystitis

Butler DSC, Ambite I, Nagy K, Cafaro C, Ahmed A, Nadeem A, Filenko N, Hien Tran T, Andersson K-E, Wullt B, Puthia M and Svanborg C.

Nature Scientific Reports, 2018

HAMLET – A protein-lipid complex with broad tumoricidal activity

Ho JCS, Nadeem A and Svanborg C.

Biochem Biophys Res Commun., 2017

Protein-dependent Membrane Interaction of A Partially Disordered Protein Complex with Oleic Acid: Implications for Cancer Lipidomics

Chaudhuri A, Prasanna X, Agiru P, Chakraborty H, Rydström A, Ho JC, Svanborg C, Sengupta D and Chattopadhyay A.

Nature Scientific Reports, 2016

Targeting of nucleotide-binding proteins by HAMLET – a conserved tumor cell death mechanism

Ho J, Nadeem A, Rydström A, Puthia M and Svanborg C.

Oncogene, 2016

Molecular basis of acute cystitis reveals susceptibility genes and immunotherapeutic targets

Ambite I, Puthia M, Nagy K, Cafaro C, Nadeem A, Butler D, Rydström G, Filenko NA, Wullt B, Miethke T and Svanborg C.

PloS Pathogens, 2016

IRF7 inhibition prevents destructive innate immunity – a target for non-antibiotic therapy of bacterial infections

Puthia M, Ambite I, Cafaro C, Butler D, Huang Y, Lutay N, Rydström G, Gullstrand B, Swaminathan B, Nadeem A, Nilsson B and Svanborg C.

Science Translational Medicine, 2016

Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation

Waldhuber A, Puthia M, Wieser A, Cirl C, Dürr S, Neumann-Pfeifer S, Albrecht S, Römmler F, Müller T, Zheng Y, Schubert S, Groß O, Svanborg C and Miethke T.